LATEST RUGBY WORLD MAGAZINE SUBSCRIPTION DEALS The Lions tour is officially underway, with the visitors turning in an error-strewn and frustrating display as they chugged to a close win over the Provincial Barbarians. Their hosts are a largely semi-pro side that can boast a trainee nurse and sheep farmer among their ranks. The Lions will want to re-focus right away on their next game, against the Auckland Blues who will be fielding their All Blacks next week.The Lions trailed at half-time 7-6, with Warren Gatland’s son, Bryn, pulling the strings from fly-half and frustrating the Lions with his array of kicking skills. Opposite him, Johnny Sexton struggled to control his side while elsewhere tackles fell off and countless passes were put behind attackers.The Lions kept at it in the second half though, nudging their way ahead thanks to an Anthony Watson try and then they crunched on. It never looked comfortable but they saw it out. They only arrived on Wednesday and are clearly still feeling the effects of their trip, but the show moves on.Below are the players who managed to stand out from the crowd and the key talking points.Stand-out: Kyle Sinckler was a rare shining light for the LionsWhich Lions caught the eye?Taulupe Faletau – With the try-line begging for the Barbarians, Faletau managed to make an incredible tackle on the slide that turned into him holding the ball up over the line. While others lost their heads around him, he kept his. And his defensive decision-making is so impressive.Kyle Sinckler – The big fella can shift and he can give and take at pace. Time and again he put his hands up to take ball on. A confident showing.Ben Te’o – There is no second-guessing with Te’o: he takes the ball to the line hard. Once his team-mates learn how he runs and how he shifts at the gainline, he will become a consistent offloading option.What’s hotA win’s a win and all that – Are Lions openers cursed to forever underwhelm? Well at no point was it pretty, but it was a win. This match won’t go down as a classic, but it pointed to plenty of points to work on for the Lions. And there’s little time to dwell on things. The weather – Okay, it wasn’t literally hot, but the rain held off. There had been torrential downpours through Friday and at the start of Saturday morning, so to have a dry night was a big plus. Particularly for those sitting on the banks of the hill on one side of the Toll Stadium.Family affair: Bryn Gatland and Warren Gatland before the gameWhat’s not Replacements: Elliot Daly.Tries: Watson. Cons: Farrell. Pens: Sexton, Laidlaw. Man on a mission: Taulupe Faletau takes the ball up for the Lions The Lions made hard work of their first match on tour, against the New Zealand Provincial Barbarians. First match jitters – From Iain Henderson missing kick-off receptions to Alun Wyn Jones going offside and Stuart Hogg butchering a two-on-one, it was a first half to forget for Lions fans. So many chances went begging for the Lions. The second half wasn’t much better, with the team with so much Test experience struggling to boss proceedings. Some of it will come down to rust and jet-lag still, of course, but they need to kick things up a gear from this point.Booing the kicker – It’s par for the course in New Zealand, but with Sexton lining up the first kick of the series, boos rang out. Passion you can understand, but it’s not like this crowd are all dyed in the wool Provincial Baa-Baas fanatics. Let both sides crack on during this series.Statistics54% – The Baa-Baas possession stats. They consistently broke the Lions.11 – The Lions penalty count, which may not sound like much, but will still be frustrating. Particularly from a defensive point of view.4 – The number of times the Lions got over the line but couldn’t touch down.NZ Provincial Barbarians: Luteru Laulala; Sam Vaka, Inga Finau (Jonah Lowe 19), Dwayne Sweeney, Sevu Reece; Bryn Gatland (Joe Webber 58), Jack Stratton (Richard Judd 57); Aidan Ross (Tolu Fahamokioa 45), Sam Anderson-Heather (capt) (Andrew Makalio 45), Oliver Jager (Marcel Renata 61), Josh Goodhue, Keepa Mewett (Peter Rowe 61), James Tucker, Lachlan Boshier (Matt Matich 46), Mitchell Dunshea.Tries: Sam Anderson-Heather. Cons: Gatland.British & Irish Lions: Stuart Hogg; Anthony Watson, Jonathan Joseph, Ben Te’o, Tommy Seymour; Johnny Sexton (Owen Farrell 48), Greig Laidlaw (Rhys Webb 58); Joe Marler (Mako Vunipola 49), Rory Best (Jamie George 49), Kyle Sinckler (Tadhg Furlong 49), Alun Wyn Jones, Iain Henderson (George Kruis 49), Ross Moriarty, Sam Warburton (capt) (Justin Tipuric 66), Taulupe Faletau. TAGS: Highlight
Save my name, email, and website in this browser for the next time I comment. Support conservation and fish with NEW Florida specialty license plate By Jennifer RobertsonWhen was the last time you went out with your coworkers for lunch? Had a breakfast meeting with your team at your favorite spot? Or attended a training seminar that wasn’t virtual?Social events are in short supply these days, but maintaining a social network is still essential – especially as millions of Americans are looking for work. Who you know is a very large part of the job search, so it’s not a stretch to say that networking can be the single most important skill in your repertoire.Most people associate the word “networking” with office parties, meetings over coffee, and professional mixers. But that’s not the whole picture. Any time you have a positive, productive interaction with someone you know (good news!) you are networking. When you chat with your cousin, sign up for your neighborhood committee, or even participate in a Zoom call with your church group, you’re forming relationships that can impact your career.Social distancing can make it harder to stay in touch with friends and family – let alone former classmates and colleagues. But it’s worth it to be proactive. By making yourself available and staying in contact, you can create and strengthen relationships that will last long after the pandemic ends.Here are six ways to get started:Review your digital footprint. A huge amount of our communication takes place online, so make sure your social media profile, posts, emails, texts, and photos reflect polish and professionalism. If an acquaintance saw your social media feed, would they recommend you to an employer? Do you proofread your emails and texts? Do you have an up-to-date resume and job history on LinkedIn?Seek new opportunities. There are still plenty of ways to stay engaged, but you won’t find them unless you look. Tune into online seminars, professional panels and virtual meet-and-greets. Invite your contacts for a happy hour or coffee over Zoom. If you’re looking for work, be open about it – and be ready to give a brief summary of your experience, skills and career. You never know who might be able to open the door to your next position.Show you care. Show that you care about your network as friends, not just as contacts. When you meet someone new, remember their name and use it. Call or message your acquaintances to ask how they’re doing. Especially now, gestures of care and concern can leave a big impression.Be professional. Not every networking opportunity is as formal as an interview, but the way you present yourself will influence how people view you. Dress a step above the dress code. (Yes, even on Zoom.) Speak clearly and confidently. Smile. Be punctual. If you’ve scheduled a meeting with someone in your network, come prepared to talk about their business or industry.Follow up. Be sure to follow up no later than 24 hours after a meeting – whether you send a letter, an email, or a sincere LinkedIn message. Thank your contact for their valuable time and let them know how much you appreciate their help.Make it a habit. Too often, people think of networking as something you do when you’re looking for a job. In reality, the best time to cultivate your network is when you least need it. That way, if you do end up in the job market, you’ll have a strong support system at the ready.Searching for a job can be difficult at the best of times, let alone during a pandemic and when competition is high due to unemployment rates. But you don’t have to do it alone. You can access free, one-on-one virtual help with a job connection team member at Goodwill for assistance with career counseling, resume help, interview practice and more. During COVID-19, you can also tune in to virtual professional development seminars on a variety of topics – including tips for identifying and expanding your network. A full list of webinars and dates can be found at www.GoodwillCFL.org.Jennifer Robertson is a job connection services virtual team member with Goodwill Industries of Central Florida. She can be reached at [email protected], or by calling (407) 235-1541. You have entered an incorrect email address! Please enter your email address here LEAVE A REPLY Cancel reply Photo by Andrew Neel on Unsplash Share on Facebook Tweet on Twitter Please enter your name here Please enter your comment! The Anatomy of Fear Free webinar for job seekers on best interview answers, hosted by Goodwill June 11 TAGSGoodwill of Central FloridaJob Connection ServicesJobsNetworkingNew Normaltips Previous articleApopka gardeners can celebrate Plant of the Month: Tomatillos and Husk TomatoesNext articleFlorida airports will continue to struggle until ban on international travel lifted Denise Connell RELATED ARTICLESMORE FROM AUTHOR
RSF_en June 2, 2021 Find out more MaltaEurope – Central Asia Protecting journalistsInternational bodies WomenCorruptionImpunityViolenceFreedom of expressionCouncil of Europe News RSF and 60 other organisations call for an EU anti-SLAPP directive Impunity remains one of the single biggest challenges to the protection of journalists. It includes 15 cases of murders of journalists and numerous cases of threats and other types of intimidation and harassment which were not investigated by State authorities. We call on Member States to adhere to the Council of Europe’s Guidelines on effective investigations to bring perpetrators of such crimes to justice, and wider measures needed to end impunity. We also ask them to continue to support the work of the Platform, in partnership with international press freedom organisations. Joint open letter to the members of the Parliamentary Assembly of the Council of Europe: Call for a PACE Special Rapporteur on Daphne Caruana Galizia’s assassination and the crimes she exposed At the winter session in Strasbourg, Daphne Caruana Galizia’s three sons will be calling for a special rapporteur to be appointed whose mandate will involve monitoring the ongoing murder investigation in Malta, investigating the broader circumstances surrounding Daphne Caruana Galizia’s death, and ensuring there is no impunity for the perpetrators of the crimes Daphne Caruana Galizia exposed. Dear Members of the Parliamentary Assembly of the Council of Europe, Daphne Caruana Galizia was by all accounts Malta’s most widely read and influential journalist. She had an immeasurable impact on Malta’s politics over the course of her thirty-year career and single-handedly uncovered some of the country’s biggest corruption scandals, exposing Maltese institutions for their unwillingness to pursue powerful and well-connected members of the country’s business and political class.Known by her hundreds of thousands of readers in Malta and elsewhere simply as ‘Daphne’, she was assassinated on 16 October 2017 in broad daylight by a remote-controlled car bomb as she left her home in Malta. Yours sincerely, January 19, 2018 RSF joins calls on Council of Europe to ensure justice for murdered Maltese journalist Daphne Caruana Galizia In 2017, we submitted 130 alerts concerning 29 countries, confirming last years’ trends of the wide geographic spread of threats to media freedom. In 79 alerts (60%) in 2017, the State was the source of the threat. Fewer than 30 percent of the alerts passed on to Member States in 2017 received a State reply. All Platform alerts have been verified by Council of Europe Partner organisations and they all deserve a reply and, we believe, appropriate follow-up action as well. Malta: Developments in murder case mark nascent steps towards justice for Daphne Caruana Galizia Help by sharing this information February 24, 2021 Find out more Daphne Caruana Galizia was murdered in a car bomb explosion on October 16, a few meters away from her home. Her death raised concerns not only about protection of critical journalists but also about the rule of law and corruption in Malta. We believe that, given the profile of the crime and the issues of corruption Daphne Caruana Galizia had worked to uncover, the investigation into her assassination demands the continued scrutiny of the international community. We join Daphne Caruana Galizia’s family in calling on the Parliamentary Assembly of the Council of Europe to appoint a special rapporteur to monitor the ongoing murder investigation and make an assessment of the contextual circumstances that led to her murder. The alerts consist mainly of attacks on physical safety and integrity of journalists (23%), harassment and intimidation (23%), and detention and imprisonment (21%). News News Related documents pace_side_event_daphne_caruana_galizia_22jan2018.pdfPDF – 830.6 KB The killing of Daphne Caruana Galizia demonstrated the dangers which journalists around Europe faced last year. The co-signatories of this call to action also express concern regarding several worsening press freedom trends. These conclusions are based on a compilation of cases of serious threats to media freedom and journalists’ safety reported on the Council of Europe Platform for the Promotion of Journalism and the Protection of Journalists. More than three months after the journalist’s brutal murder there are no public indications to suggest that the authorities have identified the people who commissioned, planned or orchestrated the murder. Ricardo Gutiérrez, General Secretary, European Federation of Journalists (EFJ) Antoine Bernard, Deputy Director General of Reporters Without Borders (RSF) Patricia Moreira, Managing Director, Transparency International Barbara Trionfi, Executive Director, International Press Institute (IPI) Carles Torner, Executive Director, PEN International Tom Gibson, EU Representative, Committee to Protect Journalists (CPJ) Anna Bevan, Assistant Director, International News Safety Institute (INSI) Ernest Sagaga, Head of Human Rights and Safety, International Federation of Journalists (IFJ) Joy Hyvarinen, Head of Advocacy, Index on Censorship Natalia Yerashevich, Director of the Secretariat, Eastern Partnership Civil Society Forum Katie Morris, Head of Europe and Central Asia, ARTICLE 19 Antonia Byatt, Interim Director, English PEN Dr Lutz Kinkel, European Centre for Press and Media Freedom (ECPMF) William Horsley, VP and Media Freedom Representative, Association of European Journalists (AEJ) Only months before, Daphne Caruana Galizia had uncovered systemic government corruption implicating senior members of her country’s government, showing how offshore structures exposed in the Panama Papers were used to receive and launder kickbacks on the sale of Maltese passports and process unexplained payments from members of Azerbaijan’s ruling family. Receive email alerts 19 January 2018 Organisation 19 January 2018 MaltaEurope – Central Asia Protecting journalistsInternational bodies WomenCorruptionImpunityViolenceFreedom of expressionCouncil of Europe News Article 19 (A19)Association of European Journalists (AEJ)Committee to Protect Journalists (CPJ)European Federation of Journalists (EFJ)Index On CensorshipInternational Federation of Journalists (IFJ)International News Safety Institute (INSI)International Press Institute (IPI)PEN InternationalReporters Sans Frontières (RSF) December 2, 2020 Find out more The undersigned organisations, partners of the Council of Europe Platform for the Promotion of Journalism and the Protection of Journalists, are deeply concerned over the lack of progress in the investigation into the murder of Maltese journalist Daphne Caruana Galizia. The authorities have announced the arrests of three suspects in connection with her murder, but there remains a widespread belief that those who ordered this crime have not yet been identified. On 19 January, Reporters Without Borders (RSF) joined a letter calling on the Parliamentary Assembly of the Council of Europe to appoint a Special Rapporteur to monitor the investigation into the murder of Maltese investigative journalist Daphne Caruana Galizia, killed by a car bomb on 16 October 2017. RSF also joined a statement of the Council of Europe Platform for the Promotion of Journalism and the Protection of Journalists calling for broader Council of Europe action to ensure justice in this case. The full text of both documents is below, along with the event flyer for a related side event RSF is pleased to co-sponsor at the Council of Europe on 22 January. In a context of complete impunity for the high-level corruption Daphne Caruana Galizia exposed and the legal, financial and other threats she faced from figures in or close to government before her assassination, her killing has underlined in shocking fashion the extent of corruption and rule of law failings in Malta. The threat to the country’s liberal democracy and press freedom is a real one: Malta has slipped sixteen places in a single year in Freedom House’s latest global ranking. ————————————————————————————— Use the Digital Services Act to make democracy prevail over platform interests, RSF tells EU In a January 2018 report of a European Parliament fact-finding mission to Malta, the country’s Commissioner of Police confirmed on record that no police investigations took place into any of Daphne Caruana Galizia’s Panama Papers revelations. The senior government figures implicated in her investigative reporting remain in public office. We ask you to heed their call and to support their efforts in every possible way in the interests of all of us who work to see justice and bring an end to impunity. to go further Daphne Caruana Galizia’s violent death and the impunity for the crimes she revealed have serious consequences in the most fundamental areas of the work of the Parliamentary Assembly of the Council of Europe. Follow the news on Malta Council of Europe’s Partner Organisations on Media Freedom Raise Alarm after Grim Record in 2017 and Urge Close International Scrutiny over the investigation into Daphne Caruana Galizia’s Murder We remind the government of Malta and all concerned that Guidelines related to judicial follow-ups to the killing of journalists approved by the Committee of Ministers of the Council of Europe in April 2016 state that “investigations must be effective to maintain public confidence in the authorities’ maintenance of the rule of law and to prevent any appearance of collusion in or tolerance of unlawful acts.” The Guidelines also recommend that “investigations should be subject to public oversight, and that the victim’s next of kin must be involved in the procedure to the extent necessary to safeguard their legitimate interests.”
News UpdatesNCLT Benches To Resume Physical Hearings From March 1 LIVELAW NEWS NETWORK23 Feb 2021 7:01 AMShare This – xThe National Company Law Tribunal (NCLT) has decided to resume physical hearing of cases filed before it from March 1. However, if any party expresses difficulty in physical hearing, he/ she may be permitted to appear via video conferencing. As per an office order issued by the Registrar, “All NCLT Benches shall start regular Physical hearing w.e.f 0l.03.2021. In case any…Your free access to Live Law has expiredTo read the article, get a premium account.Your Subscription Supports Independent JournalismSubscription starts from ₹ 599+GST (For 6 Months)View PlansPremium account gives you:Unlimited access to Live Law Archives, Weekly/Monthly Digest, Exclusive Notifications, Comments.Reading experience of Ad Free Version, Petition Copies, Judgement/Order Copies.Subscribe NowAlready a subscriber?LoginThe National Company Law Tribunal (NCLT) has decided to resume physical hearing of cases filed before it from March 1. However, if any party expresses difficulty in physical hearing, he/ she may be permitted to appear via video conferencing. As per an office order issued by the Registrar, “All NCLT Benches shall start regular Physical hearing w.e.f 0l.03.2021. In case any counsel/ representative of party expresses difficulty in physical hearing, he/ she may be permitted for virtual hearing.” The Principal Bench of the NCLT shall comprise of BSV Prakash Kumar (Acting President) and Hemant Kumar Sarangi (Member). Further, five Division Benches will function in the prescribed alternate arrangement at Delhi, two Division Benches shall be functional in Chennai and five in Mumbai (of these two Division Benches will function in an alternate fashion). Access the Officer Order attached below to access Bench constitution of all NCLT Benches. Click Here To Download Order Read OrderSubscribe to LiveLaw, enjoy Ad free version and other unlimited features, just INR 599 Click here to Subscribe. All payment options available.loading….Next Story
Satellites can be damaged by high energy charged particles in the Earth’s radiation belts and during solar energetic particle (SEP) events. Here we review the growing reliance on satellite services, new vulnerabilities to space weather, and previous events that have led to loss of service. We describe a new European system to forecast the radiation belts up to 3 h ahead, which has three unique features: first, it uses physics-based models, which include wave-particle interactions; second, it provides a forecast for the whole outer radiation belt including geostationary, medium, and slot region orbits; third, it is a truly international effort including Europe, United States, and Japan. During the 8–9 March 2012 storm and SEP event, the models were able to forecast the >800 keV electron flux to within a factor of 2 initially, and later to within a factor of 10 of the GOES data. Although ACE and GOES data became unreliable during the SEP event, the system continued forecasting without interruption using ground-based magnetometers. A forecast of the 24 h electron fluence >2 MeV is used to provide a risk index for satellite operators. We show that including wave-particle interactions for L* > 6.5 improves the agreement with GOES data substantially and that a fast inward motion of the magnetopause to L* < 8 is related to rapid loss of relativistic electrons at geostationary orbit. Thus, we suggest that better wave-particle models and better coupling between the solar wind and the models of the magnetopause and radiation belts should lead to better forecasting.
On the aspect of repeatability, Walker reported that whilst most of his results were repeatable, he sometimes observe large variations in his results and said “I have not been able to resolve the controversy”. Having boiled some milk for making ice cream, his class were told to let the mixture cool before putting it in the refrigerator. Mpemba, however was anxious of ensuring himself a space so put his mixture in straight away. I said Mpemba re-discovered this; having mentioned this “Mpemba Effect” in one of their articles, the “New Scientist” was subsequently flooded with anecdotes from all over the world of only the hot water pipes freezing during a short cold snap, ice-rink operators preferring to use hot water and so on. Osborn and Mpemba published these results in a journal called “Physics Education”, coincidentally the same year that George Kell at the National Research Council of Canada in Ottawa reported the same phenomenon that year in the “American Journal of Physics”. In a subsequent year at high school Mpemba was taught about Newton’s law of cooling in science: the rate at which a body cools is proportional to the temperature difference between that body and its surroundings:…which leads to the solution… Any set of cooling curves plotted from such a function will never cross, no matter what the initial starting temperature. So a curve which starts at a higher temperature will never undercut a curve starting at a lower temperature and will therefore always take longer to cool. Varying the parameter k on the other hand could well cause graphs to cross. But this parameter is determined from some initial conditions, if both systems are not identical in such things as geometry or arrangement, with the exception of starting temperature, then it is hardly appropriate to compare cooling times for different initial temperatures. The lab-assistant reported the hot water had frozen first, but not to worry, “I’ll keep on repeating the experiment until we get the right result.” After several attempts it seemed Mpemba was right – hot water would freeze faster than cold water. However, Mpemba was undeterred by a theory which didn’t seem to support his observations: he’d asked a friend who sold ice cream in a nearby town who told him he routinely used hot mixtures because they froze more quickly. Still persisting with this, in 1969 a visiting academic from University College in the capital called Dr Osborne came to visit Mpemba’s school and he jumped at the opportunity to quiz him about this apparent violation of Newton’s Law. Thankfully he didn’t dismiss it outright, and upon returning to Dar es Salaam, he instructed a lab-assistant to carry out an experiment to see if hot water would freeze more quickly than cold water. Publish or perish He came away with the simple observation that “hot liquids freeze faster than cold liquids”.His science teacher told him this was impossible and he must have got mixed up. So why exactly is this impossible? So this clearly wasn’t unheard of. Mpemba was a secondary school student in Tanzania in 1963 who had the fortune of re-discovering some interesting physics during one of his cookery lessons. Surely the validity of this effect can be deduced by carrying out experiments – however this has proved surprisingly difficult. The Mpemba effect is only observed under certain conditions – there are clearly many factors which could affect how quickly water cools such as the geometry of the container, the volume of water and the temperature of the refrigerator. In 1977, Jearl Walker published results in the “Scientific American” whereby the time to freeze was measured against the initial temperature for a variety of containers. His results showed two things. Firstly where negative gradients occur, water at an initially higher temperature appeared to be freezing more quickly. Secondly, this is by no means a universal effect, since most of the curves showed very little (if any) in the way of negative gradients. The other students waited and put their mixtures in later, after they’d cooled down. Having noted the time his ice cream entered the freezer compared with the rest of his class, Mpemba realised his mixture had frozen significantly faster than everyone else’s. So assuming both Newton and Mpemba are correct – how do we understand what is going on here? Can we somehow reconcile these two arguments? CHECK BACK NEXT WEEK TO FIND OUT…by Will Frass
POLAND — A traffic chase turned into a foot pursuit for Chautauqua County Sheriff’s Deputies with K-9 Link apprehending a Jamestown man.Deputies attempted to stop Thomas Kimbrough Sr., 50, for an observed traffic violation at 11:32 p.m. Sunday on Main Street in Falconer.Deputies said the suspect fled the scene and the vehicle chase ended when Kimbrough crashed into a tree on Quaint Road.Deputies said he then fled on foot into the woods. K-9 Officer Link, while trailing Kimbrough, founds 19 grams of fentanyl, 15 grams of cocaine, 29 grams of methamphetamine, scales, packaging and a large amount of money.Link found Kimbrough in dense bushes.Kimbrough was charged with three counts of fourth-degree criminal possession of a controlled substance, third-degree unlawful fleeing police, several traffic violations and parole violation on an original charge of fourth-degree criminal possession of a controlled substance. Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window)
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22-Sep2:20 AMMedical Trauma500 block N. Elm 22-Sep12:58 AMFire Alarm1100 block Shady Lane 24-Sep6:51 PMMedical Emergency1600 block W. 8th 24-Sep1:00 PMTransfer to Wichita 24-Sep3:05 PMMedical Emergency1100 block North C 25-Sep3:45 AMFire Alarm200 block Cherry Blossom 27-Sep6:40 PMMedical Emergency1900 block Madison 21-Sep12:59 PMMedical Emergency700 block North A 21-Sep12:30 PMMedical Trauma1600 block W. 16th 23-Sep9:16 PMMedical Emergency1000 block College 24-Sep4:12 PMMedical Emergency1000 block College 23-Sep9:16 PMMedical Emergency1000 block College 25-Sep8:05 PMVehicleÂ Accident200 block E. 15th Street South 24-Sep1:15 AMFire InvestigationRock Rd. & 170th South 21-Sep12:59 PMMedical Emergency700 block North A 21-Sep1:22 AMMedical Alarm1900 block Madison 21-Sep11:07 AMMedical Trauma300 block S. Blaine 26-Sep9:04 AMMedical Emergency500 block Morningside Dr 24-Sep4:12 PMMedical Emergency1000 block College 21-Sep3:45 AMMedical Alarm800 block E. 20th South 21-Sep9:08 PMTransfer to Wichita 24-Sep1:15 AMFire InvestigationRock Rd. & 170th South 22-Sep2:20 AMMedical Trauma500 block N. Elm 25-Sep5:20 AMMedical EmergencyOxford 9/25/15 13:49Medical Trauma900 S. Broadway 25-Sep8:05 PMVehicleÂ Accident200 block E. 15th Street South 21-Sep3:45 AMMedical Alarm800 block E. 20th South 22-Sep12:58 AMFire Alarm1100 block Shady Lane 21-Sep11:07 AMMedical Trauma300 block S. Blaine Wellington Fire & EMS Weekly Run Log 24-Sep11:16 PMMedical Emergency300 block E. 15th 27-Sep7:37 PMMedical Emergency1900 block Madison 24-Sep1:00 PMTransfer to Wichita 24-Sep6:51 PMMedical Emergency1600 block W. 8th 24-Sep11:16 PMMedical Emergency300 block E. 15th September 21 through September 27th 24-Sep12:09 PMMedical Emergency1000 block Shady Lane 21-Sep12:30 PMMedical Trauma1600 block W. 16th 27-Sep6:40 PMMedical Emergency1900 block Madison 21-Sep9:08 PMTransfer to Wichita 24-Sep12:09 PMMedical Emergency1000 block Shady Lane 26-Sep9:04 AMMedical Emergency500 block Morningside Dr 24-Sep9:40 AMMedical EmergencyOxford 25-Sep7:40 PMTransfer to Wichita 9/25/15 13:49Medical Trauma900 S. Broadway 25-Sep5:20 AMMedical EmergencyOxford 25-Sep3:45 AMFire Alarm200 block Cherry Blossom 25-Sep1:48 AMFire Alarm200 block Cherry Blossom 25-Sep1:48 AMFire Alarm200 block Cherry Blossom 24-Sep9:40 AMMedical EmergencyOxford 21-Sep1:22 AMMedical Alarm1900 block Madison 24-Sep1:40 AMMedial Emergency200 block South F 25-Sep7:40 PMTransfer to Wichita 24-Sep3:05 PMMedical Emergency1100 block North C 24-Sep1:40 AMMedial Emergency200 block South F Sumner Newscow report â€” The Wellington Fire and EMS weekly run log for Sept. 21 through Sept. 27, 2015. 27-Sep7:37 PMMedical Emergency1900 block Madison
A husband and wife team from Hebrew University has revealed the structure of the spliceosome, one of the most complex molecular machines in the cell (see 09/12/2002 headline), in more detail than ever before, says EurekAlert. The spliceosome is responsible for cutting out the introns in messenger RNA after it has transcribed DNA, and also for “alternative splicing” that rearranges the exons to produce a variety of proteins from the same DNA template: “Alternative splicing, which underlies the huge diversity of proteins in the body by allowing segments of the genetic code to be strung together in different ways, takes place in the spliceosome as well.” The Sperlings found a tunnel between the two major subunits of the machine where they believe the cutting and splicing operations take place, and also a cavity that might provide a safe haven for the messenger RNA strand, like a waiting room, before its surgery. Also, they found that four spliceosomes are bound together into a “supraspliceosome” which is able to do “simultaneous multiple interactions, rather than by a stepwise assembly” as inferred from other experiments in vitro. Their investigation in vivo (within a functioning, living cell) revealed even more complexity in the composite machine than had been seen in the individual machines:Such a large number of interactions that the cell has to deal with can be regulated within the supraspliceosome. Having the native spliceosomes as the building blocks of this large macromolecular assembly, this large number of interactions can be compartmentalized into each intron that is being processed. At the same time, the whole supraspliceosome enables the communication between the native spliceosomes, which is needed for regulated splicing. The organization of the supraspliceosome, like other macromolecular assemblies that exist as preformed entities, avoids the necessity to recruit the multitude of splicing components each time the spliceosome turns over. In that sense, the overall coordination of the cellular interactions is reduced from the hard work of repeatedly placing each piece in the correct position of the puzzle to the relatively simpler work of coordinating the preformed puzzle. (Emphasis added in all quotes.)In short, “The supraspliceosome represents a stand-alone complete macromolecular machine capable of performing splicing of every pre-mRNA independent of its length or number of introns.” They found that the individual spliceosomes are joined with a flexible joint like a hinge to provide flexible interactions and communication. Their work was published in Molecular Cell Sept. 10.11Sperling et al., “Three-Dimensional Structure of the Native Spliceosome by Cryo-Electron Microscopy,” Molecular Cell, Volume 15, Issue 5, 10 September 2004, Pages 833-839; doi:10.1016/j.molcel.2004.07.022.Can’t get enough of these molecular machines. And can’t repeat often enough that the more detail a scientific paper reveals about the complex workings inside the cell, the less they have to say about evolution. Quiz: how many times was evolution mentioned in this paper? Answer: zilch, zero, nada. They didn’t even say, “watch this space.” (see 09/08/2004 commentary). (Visited 12 times, 1 visits today)FacebookTwitterPinterestSave分享0