Wolf 5 Pittsburgh Steelers​ 4 Detroit Lions 3 N

first_imgWolf5) Pittsburgh Steelers​4) Detroit Lions3) New England Patriots2) Kansas City Chiefs1) Atlanta Falcons“When you look at a team that has one loss now, you got to look at all the other 2-1 teams and say ‘O.K. who has a better loss? Who’s O.K. with a loss?’ I would say I am going with the Oakland Raiders,” Doug said. “Not a good loss to the Washington Redskins, you’re a better team than that, but when you fly across the country crap can happen and the Redskins were on fire. I am going to give Oakland as one of the best losses and say they are the team.”After starting 2-0 and looking like a team to beat, the Raiders’ offense fell flat Sunday night, losing to the Redskins 27-10. Quarterback Derek Carr was under pressure for most of the night and it showed. He threw for less than 125 yards and had two interceptions in the loss. Running back Marshawn Lynch couldn’t find the holes, only rushing for 18 yards and sitting out most of the fourth quarter.At the top of the Doug and Wolf’s lists were the only unbeaten teams left in NFL in the Kansas City Chiefs and the Atlanta Falcons.“Look at that nice win over Green Bay, look at the way they are playing, the Atlanta Falcons are the second-best team in the NFL,” Doug said. Your browser does not support the audio element. You can hear their explanation for their other picks by listening to the podcast above, and you can also catch their weekly rankings live on 98.7 FM, Arizona’s Sports Station. The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Derrick Hall satisfied with D-backs’ buying and selling 0 Comments   Share   Top Stories LISTEN: Doug & Wolf NFL Power Poll – Week Four With Week 3 in the books, the NFL is looking a little different from what people had originally pictured coming into the season.In the middle of it all, 98.7 FM Arizona’s Sports Station’s own Doug and Wolf took another crack at their weekly NFL Power Poll that ranks the best teams in the league, according to the two.Here’s what they came up with this week:Doug5) Oakland Raiders4) Green Bay Packers3) New England Patriots2) Atlanta Falcons1) Kansas City Chiefs Former Cardinals kicker Phil Dawson retires Grace expects Greinke trade to have emotional impactlast_img read more

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Study pinpoints immune cells that could be key to tackling hypertension

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Jan 16 2019Scientists have pinpointed cells in the immune system that could be key to tackling high blood pressure.The findings also shed light on current medications that could increase risk of the disorder, which affects more than 12 million people in the UK.High blood pressure – or hypertension – is a leading cause of life-threatening conditions including heart attack, kidney disease and stroke.The study revealed a new role for specialized white blood cells – known as macrophages – that are central to the body’s immune system.Researchers led by the University of Edinburgh discovered that macrophages scavenge for and ‘eat’ molecules of a powerful hormone known as endothelin.By monitoring and regulating endothelin levels in the blood, these white blood cells help blood vessels relax, significantly lowering blood pressure.Related StoriesRetina can restructure itself following gene therapyStudy: Megakaryocytes play an important role in cell migrationSlug serves as ‘command central’ for determining breast stem cell healthThe scientists found that lowering levels of macrophages increased blood pressure in mice fed a high salt diet. When the macrophage level returned to normal, blood pressure also normalized.The same findings were replicated in mice genetically bred with a deficiency of the endothelin system and in mice with drug-induced high blood pressure.The researchers then looked at white blood cells in patients taking medication for an immune system disorder that attacks blood vessels.Those taking medication known to reduce macrophages had higher blood pressure compared with patients taking other medications.Scientists say these findings could help spot people most at risk of developing hypertension. The study could open avenues to improve current therapies, although researchers caution that further human studies are needed.The study, published in the European Heart Journal, was funded by the British Heart Foundation.Professor Matthew Bailey, Chair in Renal Physiology at the University of Edinburgh’s British Heart Foundation Centre of Research Excellence, who led the study, said: “Hypertension affects millions of people across the globe, including 70 per cent of people over 70.”Our discovery sheds light on risk factors, and crucially, opens routes to investigate new drugs that could help patients. Our next steps will be to investigate the role of macrophages in people living with hypertension.”Jeremy Pearson, Associate Medical Director at The British Heart Foundation, said: “In the UK, an estimated 6.8 million people are living with undiagnosed high blood pressure. This causes damage to the heart and blood vessels, putting you at risk of a potentially fatal heart attack or stroke. But we still don’t fully understand all the mechanisms that lead to high blood pressure.”This study shows for the first time that macrophages – a type of cell that helps regulate our immune responses – can be involved in the control of blood pressure. More research is needed but these cells could be a new target for drugs to treat the condition.” Source:https://www.ed.ac.uk/last_img read more

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New technique uses ultrasound to align living cells in engineered tissues

first_img Source:https://news.ncsu.edu/2019/04/ultrasound-aligns-living-cells-in-bioprinted-tissues/ Reviewed by James Ives, M.Psych. (Editor)Apr 11 2019North Carolina State University researchers have developed a technique to improve the characteristics of engineered tissues by using ultrasound to align living cells during the biofabrication process.”We’ve reached the point where we are able to create medical products, such as knee implants, by printing living cells,” says Rohan Shirwaiker, corresponding author of a paper on the work and an associate professor in NC State’s Edward P. Fitts Department of Industrial & Systems Engineering. “But one challenge has been organizing the cells that are being printed, so that the engineered tissue more closely mimics natural tissues.”We’ve now developed a technique, called ultrasound-assisted biofabrication (UAB), which allows us to align cells in a three-dimensional matrix during the bioprinting process. This allows us to create a knee meniscus, for example, that is more similar to a patient’s original meniscus. To date, we’ve been able to align cells for a range of engineered musculoskeletal tissues.”To align the cells, the researchers built an ultrasound chamber that allows ultrasonic waves to travel across the area where a bioprinter prints living cells. These ultrasonic waves travel in one direction and are then reflected back to their source, creating a “standing ultrasound wave.” The soundwaves effectively herd the cells into rows, which align with areas where the ultrasound waves and the reflected waves cross each other.”We can control the alignment characteristics of the cells by controlling the parameters of the ultrasound, such as frequency and amplitude,” Shirwaiker says.Related StoriesPassive cavitation imaging can estimate a drug’s dose and location in the brainUCLA physicians find more effective method for detecting prostate cancerUsing machine learning algorithm to accurately diagnose breast cancerTo demonstrate the viability of the UAB technique, the researchers created a knee meniscus, with the cells aligned in a semilunar arc – just as they are in a natural meniscus.”We were able to control the alignment of the cells as they were printed, layer by layer, throughout the tissue,” Shirwaiker says. “We’ve also shown the ability to align cells in ways that are particularly important for other orthopedic soft tissues, such as ligaments and tendons.”The researchers also found that some combinations of ultrasound parameters led to cell death.”This is important, because it gives us a clear understanding of both what we can do to improve tissue performance and what we need to avoid in order to preserve living cells,” Shirwaiker says.To that end, the researchers have created computational models that allow users to predict the performance of any given set of parameters before beginning the biofabrication process.One other benefit of the UAB technique is that it is relatively inexpensive.”There’s a one-time cost for setting up the ultrasound equipment – which can use off-the-shelf technology” Shirwaiker says. “After that, the operating costs for the ultrasound components are negligible. And the UAB technique can be used in conjunction with most existing bioprinting technologies.”We have a patent pending on the UAB technique, and are now looking for industry partners to help us explore commercialization,” Shirwaiker says.last_img read more

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Bihar Man commits suicide in Nalanda police custody

first_img Next Asian News International NalandaJuly 12, 2019UPDATED: July 12, 2019 13:59 IST Picture for representationA man allegedly committed suicide in police custody in Nalanda Police station on Thursday.The man was brought to the police station for questioning in a kidnapping case.AK Singh, Assistant Sub-Inspector, Nalanda Police station, said, “We brought him for questioning with regard to the kidnapping of a girl and after interrogation, we would have set him free. But he committed suicide by hanging himself. We immediately rushed him to the hospital for medical assistance but the doctor declared him dead.”An investigation has been initiated to ascertain the reason behind his death.Also read: Cricket fan dies in Bihar while watching thrilling IND vs NZ matchALSO WATCH| Nobody can win 100 out of 100 matches: Sachin Tendulkar after India crash out of World CupFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byIram Ara Ibrahim Bihar: Man commits suicide in Nalanda police custodyAn investigation has been initiated to ascertain the reason behind his death. advertisementlast_img read more

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